The live television show Agenda will broadcast Fredrik Reinfeldt, who is head of the Moderate Party, and the Social Democrat Stefan Löfven alongside the other leaders of parties who have seats in parliament.
För Löfven, this will be his first live debate. His predecessor, Håkan Juholt, refused to participate in the debate last year in protest because the leader of the anti-immigration party the Sweden Democrats was placed next to the left-of-centre opposition parties on the debate floor.
Löfven is not an MP, having been chosen to take over the then ailing Social Democrats while he was still in charge of the national Metal Union, and has not been able to engage in debate with Reinfeldt in parliament.
Gustav Fridolin and Jonas Sjöstedt of the smaller parties the Greens and the Left Party are also set to make their television debate debut.
Sweden goes to the polls in two years' time.